Impairment of forepaw function in type 1 diabetic rats
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School of Medicine, RCSI Bahrain, Bahrain
Department of Physiology, AGU – Arabian Gulf University, Bahrain
Publication date: 2023-02-20
Current Topics in Diabetes 2022;2(3-4):225-229
Hand function disruption occurs in diabetes. We aimed to record this food-handling behaviour in a rat model of diabetes type 1.

Material and Methods:
The hand vermicelli test measures practised forepaw use in rats, which can model diseases such as brain injuries. This test demonstrates in a dexterous way how rats handle food items with their paws.

When rats manipulate pasta, such as vermicelli, they adjust their forepaw hold on the pasta. These adjustments can be easily viewed, counted, and recorded. Diabetic type 1 rats experienced statistically significant reductions in adjustments made with the right and left fingers. There was an increase in several atypical handling patterns for the experimental group, an increased eating time of 120 seconds, and increased adjustments made with the left forepaw, compared to the control group.

The abnormal handling patterns and increased eating time may indicate compensatory measures to cope with diabetes-induced motor impairment.

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